glucuronic acid conjugation pathway

Conjugation

First let us learn what is metabolism of xenobiotics Detoxification – The series of biochemical reactions occurring in the body to convert foreign compounds to non-toxic and more easily excretable form Xenobiotic is any foreign or strange substance to the body Detoxification of this is called metabolism of xenobiotics The metabolism of xenobiotics is ConjugationRead More

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Petra Jancovaa* Pavel Anzenbacherb Eva Anzenbacherova

In man and some other species conjugation with glucuronic acid represents by far the most important metabolic pathway A couple of studies have shown in-terspecies differences in the glucuronidation process For example differences in the formation and stereoselectiv-ity of silybin glucuronides by liver microsomes of man monkey pig dog and rat were described by Matal et al 39 Species

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4 Liver and Biotransformation of Xenobiotics • Functions

1) Glucuronic acid Glucuronic acid is the most common conjugation agent It is necessary to activate it by UTP thus UDP-glucuronate is produced Only this form is able to react with xenobiotic molecule – conjugation is catalysed by the enzyme UDP-glucuronyltransferase

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Glucuronate

glucuronic acid[glkyərnik ′asəd] (biochemistry) C6H10O7 An acid resulting from oxidation of the CH2OH radical ofD-glucose to COOH a component of many polysaccharides and certain vegetable gums Also known as glycuronic acid Glucuronic Acid one of the uronic acids COH(CHOH)4COOH it is formed in the body from glucose when the latter

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Search results for UGT1A1

Members of the UGT2 subfamily are each encoded by their own genes in contrast to UGT1As which are encoded at the UGT1 locus Example substrates are morphine conjugation by UGT2B7 and androgenic steroid conjugation by UGT2B17 Xenobiotics conjugated with glucuronic acid can be substrates for beta-glucuronidase an enzyme common in gut microflora

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Steroids Cholesterol and Bile Acid: Lipid Metabolism

Steroids and Bile Acid: Lipid Metabolism Steroids and Bile Acid: Lipid Metabolism Last update March 19 2020 (Votes: 8 average: 4 25) Another pathway for bile acid synthesis is through the hydroxylation of cholesterol at the 27 position by the mitochondrial enzyme sterol 27-hydroxylase Do you want to learn even more? Start now with 1 0 00+ free video lectures given by award-winning

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Glucuronic acid Medical search Web

Glucuronic acid English English Espaol Portugus Franais Italiano Svenska Deutsch Home page Questions and answers Statistics Contact Anatomy 12 Bile Cell Wall Microsomes Liver Liver Cartilage Microsomes Lysosomes Feces Chick Embryo Cells Cultured Kidney Cell Line Organisms 8

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Conjugation

First let us learn what is metabolism of xenobiotics Detoxification – The series of biochemical reactions occurring in the body to convert foreign compounds to non-toxic and more easily excretable form Xenobiotic is any foreign or strange substance to the body Detoxification of this is called metabolism of xenobiotics The metabolism of xenobiotics is ConjugationRead More

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Conjugated vs unconjugated bilirubinemia

Conjugated vs unconjugated bilirubinemia Oct 30 The unconjugated bilirubin is then sent to the liver which conjugates the bilirubin with glucuronic acid making it soluble in water There will still be hyperbilirubinemia even if the liver can keep up with the conjugation process

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Glucuronic Acid: A Study of Its Chemistry and Role in

Glucuronic Acid: A Study of Its Chemistry and Role in Animal Metabolism Paul John Язык: english File: PDF 12 42 Читать онлайн Send-to-Kindle or Email Please login to your account first Need help? Please read our short guide how to send a book to Kindle Save for later Post a Review You can write a book review and share your experiences Other readers will always

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Glucuronidation

During glucuronidation the enzyme uridine diphosphate-glucuronosyltransferrase catalyzes the conjugation of things such as free carcinogens and steroid homones to a glucuronic acid The glucuronide-bound toxins and hormones are then safely excreted in the bile and the urine Many of the commonly prescribed drugs are detoxified through this pathway

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Aliphatic Secondary Alcohols Ketones and Related

Summary of results of the safety evaluations of aliphatic secondary alcohols ketones and related esters used as Detoxicated by reduction of the ketone followed by glucuronic acid conjugation of the corresponding alcohol or direct glucuronic acid conjugation of the secondary alcohol : 2 Detoxicated by hydrolysis of the ester and glucuronic acid conjugation of the resulting alicyclic

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DMD 36:623–630 2008 Glucuronidation of Polychlorinated

conjugation of OH-PCBs (Tampal et al 2002 Daidoji et al 2005 Sacco and James 2005 Wang et al 2006) particularly by glucuroni-dation which is normally a higher capacity pathway than sulfonation Glucuronidation is catalyzed by a family of microsomal enzymes the UDP-glucuronosyltransferases (UGTs) and requires the cosubstrate uridine 5-diphosphoglucuronic acid (UDPGA) UGTs are

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Glucuronidation

The glucuronosyltransferases (UGTs) then catalyze the transfer of glucuronic acid from UDPGA to a substrate resulting in a glucuronidated substrate and leaving uridine 5'-diphosphate UGTs are a very broad and divers group of enzymes and count as the most significant group of conjugation enzymes in xenobiotic metabolism qualitatively because glucuronic acid can be coupled to a large diversity

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Petra Jancovaa* Pavel Anzenbacherb Eva Anzenbacherova

In man and some other species conjugation with glucuronic acid represents by far the most important metabolic pathway A couple of studies have shown in-terspecies differences in the glucuronidation process For example differences in the formation and stereoselectiv-ity of silybin glucuronides by liver microsomes of man

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Metabolic Pathways

1) Glucuronic Acid Conjugation (Glucuronidation) This is the most common conjugative pathway in drug metabolism for the following reasons: 1 The body has a readily available supply of D-glucose-1-phosphate which it can convert to D-glucuronic acid 2 Numerous functional groups can be attached to glucuronic acid (flexibility)

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THE PENTOSE PHOSPHATE PATHWAY

URONIC ACID PATHWAY A pathway for conversion of glucose to glucuronic acid ascorbic acid and pentose It does not lead to generated of ATP Glucuronic acid is formed by oxidation of UDPglucose by UDPglucose dehydrogenase Glucuronic acid used for conjugation with many endogenous (bilirubin steroid hormones) and exogenous (drugs) substances before

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Analysis of the most appropriate risk management option (RMOA)

ANALYSIS OF THE MOST APPROPRIATE RISK MANAGEMENT OPTION (RMOA) _____ EC no 204-881-4 Anses (on behalf FR-MSCA) Page 3 sur 48 Disclaimer: The author does not accept any liability with regard to the use that may be made of the information contained in this document

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Glucuronic acid

Conjugation with glucuronic acid is a major pathway in the biotransformation and elimination of a wide variety of lipophilic compounds of both endogenous and exogenous origin (Coughtrie 1992 Dutton 1980) The glucuronides formed are in general less biologically active and more polar than their aglycone substrates and are hence more readily

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How the Liver Detoxifies

The Amino Acid Conjugation Pathway: the amino acids used include glycine taurine glutamine arginine and ornithine This pathway eliminates toluene (a solvent) benzoate (a food preservative) and other chemicals from the environment This process also requires the body to be alkaline and not acidic

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Conjugates comprising a central nervous system

14 07 2005Gamma aminobutyric acid (GABA) that does not cross the blood brain barrier has been rendered active as a CNS drug by lipophilic conjugation (gabapentin U S Pat No 4 894 476) and a similar fatty acid conjugation of dopamine is also known (U S Pat Nos 4 939 174 6 107 499) Glycinated pro-drugs (e g valproic acid-glycine) are known to cross the blood brain barrier utilizing

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