glucuronic acid conjugation

Metabolism Of Xenobiotics (detoxification Reactions

Q 1-The major detoxification reactions involved in phase -1 are all except: Oxidation Reduction Hydrolysis Acetylation Epoxidation Q 2- The hydroxylated products of phase-1 are converted to soluble metabolites by coupling with polar agents in phase -2 of detoxification reactions by a process called Conjugation

Request A Quotation!

Conjugation Pathways in Nicotine Metabolism

Summary Nicotine cotinine and trans-3′-hydroxycotinine are excreted as glucuronic acid conjugates in urine of tobacco users The average ratios between free and conjugated alkaloids in 24-hour urine samples from tobacco users are 1 0 0 5 and 2 3 for nicotine cotinine and trans-3′-hydroxycotinine respectively Nicotine cotinine and trans-3′-hydroxycotinine and their glucuronides

Request A Quotation!

Glucouronic acid pathway and biotransformation

Glucuronic acid should not be confused with gluconic acid a linear carboxylic acid resulting from the oxidation of a different carbon of glucose Gluconic acid a crystalline acid C6H12O7 obtained by oxidation of glucose and used chiefly in cleaning metals and as the source of its salts some of which are used medicinally 4 CONT

Request A Quotation!

Glucuronic acid

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid) The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e g chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN) UDP-glucose is a precursor of glycogen and can be converted into UDP

Request A Quotation!

Isolation of the Glucuronic Acid Conjugate of N

The glucuronic acid conjugate of N -hydroxy-4-aminobiphenyl (NOH-4-ABP) has been isolated in relatively pure form from the urine of dogs given 4-aminobiphenyl utilizing molecular size ion exchange adsorption and partition chromatography This conjugate is an active mutagen in Salmonella typhimurium strains TA1538 and TA98 but not in TA1535 or TA1537

Request A Quotation!

Evaluating Liver Test Abnormalities: Bilirubin

This bilirubin is initially water-insoluble bilirubin (unconjugated bilirubin) and is transported in blood bound to albumin It is then taken up by hepatocytes where it becomes water-soluble through its conjugation with glucuronic acid Conjugated bilirubin is then excreted into the bile canaliculus and is eventually secreted into the duodenum

Request A Quotation!

Valproic Acid Toxicity

Valproate is a simple Fatty Acid 2-n-propylpentanoic acid Eight carbon branched-chain carboxylic acid Metabolism: Three primary mechanisms Hepatic Glucuronidation (50%) Glucuronic acid conjugation occurs in the liver Primary metabolism pathway Non-hepatic metabolism Mitochondrial Beta-oxidation (40%) Primary and preferred non-hepatic pathway

Request A Quotation!

Conjugation combining of the molecule with glucuronic or

-Conjugation – combining of the molecule with glucuronic or sulfuric acid -Reduction – the opposite of oxidation in which the molecule becomes more negatively charged by graining one or more electrons o Amanita Muscaria – shrooms cannot be metanolised just excreted as whole molecules Hepatic system – the molecules can be further metabolized in the liver

Request A Quotation!

Lamotrigine Serum

Lamotrigine oral bioavailability is very high (approximately 98%) The drug is metabolized by glucuronic acid conjugation to inactive metabolites The half-life is 25 to 33 hours in adults but decreases with concurrent use of phenytoin or carbamazepine (13-14 hours) and increases with concomitant valproic acid therapy (59-70 hours) renal

Request A Quotation!

Effect of inducers and inhibitors of glucuronidation on

Valproic acid (VPA) induces an immediate choleresis in the rat which may be attributable to the osmotic properties of VPA-glucuronic acid conjugates in bile The influence of inducers and inhibitors of glucuronidation of VPA on the biliary excretion and choleretic effect of VPA was studied Hepatic UDP-glucuronyltransferase activity toward VPA was determined in vitro

Request A Quotation!

Alfa Aesar D

D-Glucuronic acid is used as pharmaceutical intermediate and in chemical research Solubility Soluble in water Notes Store in cool place Keep container tightly closed in a dry and well-ventilated place Incompatible with strong oxidizing agents Specifications Melting Point bsim 158C (decomposition) Quantity: 5g: Optical Rotation plus 35 (cequals 6 in Water) Beilstein: 1727083: Merck

Request A Quotation!

Glucuronide

Glucuronide formation is the commonest conjugation in mammals presumably from the ready availability of glucuronic acid in the tissues and the many chemical groups forming glucuronides Enzymes catalyzing glucuronide synthesis have been widely if not deeply studied and exhaustive references up to 1965 are available ( Dutton 1966 b)

Request A Quotation!

glucuronic acid

Conjugation with glucuronic acid is the major [] metabolic pathway for morphine purdue ca purdue ca La conjugaison avec l'acide glucuronique constitue [] la principale voie mtabolique pour la morphine purdue ca purdue ca A fortified foodstuff comprising from 0 05 to 5% by weight based on the weight of the foodstuff of [] a balanced blend consisting solely of calcium lactate

Request A Quotation!

The Ubiquitous Co

The Ubiquitous Co-Enzyme UDPGlucuronic Acid Detoxifying Agent in Kombucha Tea? By Norbert Hoffmann Glucuronic acid is considered by many to be one of the important key components found in Kombucha Tea because of its detoxifying action It is widely distributed in plants found in gums mucilages saponines etc and in animals The related compound UDPGlucuronic acid which is the

Request A Quotation!

Glucuronidation (Mus musculus)

First in a series of reactions the cosubstrate uridine diphosphate glucuronic acid (UDPGA) is formed The glucuronosyltransferases (UGTs) then catalyze the transfer of glucuronic acid from UDPGA to a substrate resulting in a glucuronidated substrate and leaving uridine 5'-diphosphate UGTs are a very broad and divers group of enzymes and count as the most significant group of conjugation

Request A Quotation!

Glossary: Glucuronic acid

Glucuronic acid (C 6 H 10 O 7) a derivative of glucose is produced in the liver of humans and most animals It is a highly soluble compound that can bind to substances such as hormones drugs and toxins to facilitate their transport around the body In this way glucuronic acid is largely responsible for the elimination of poisonous substances such as PCBs Source: GreenFacts Related

Request A Quotation!

Metabolic Conjugation and Metabolic Hydrolysis

The glucuronic acid pathway is also discussed along with sulfoconjugation and sulfohydrolysis Comprised of eight chapters this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations

Request A Quotation!

Routes of conjugation in normal and cancerous tissue from

Conjugation with glucuronic acid and sulphate constitute two of the most important pathways of metabolism of drugs other foreign compounds and hormonal steroids 2 3 Using 1-naphthol as a model phenolic substrate normal peripheral lung tissue formed almost exclusively the sulphate ester conjugate 1-naphthyl sulphate whereas tumour tissue

Request A Quotation!

Glucuronide and glucoside conjugation of mycophenolic acid

glucosidation of this acid (Little et al 1995) However the contribution of extrahepatic tissues to the formation of such a glucoside has not yet been investigated The aim of the present investigation was to compare the glucuronide and glucoside conjugation of MPA by human liver kidney and intestinal microsomes To better under-

Request A Quotation!

Conjugation Pathways in Nicotine Metabolism

Summary Nicotine cotinine and trans-3′-hydroxycotinine are excreted as glucuronic acid conjugates in urine of tobacco users The average ratios between free and conjugated alkaloids in 24-hour urine samples from tobacco users are 1 0 0 5 and 2 3 for nicotine cotinine and trans-3′-hydroxycotinine respectively Nicotine cotinine and trans-3′-hydroxycotinine and their glucuronides

Request A Quotation!
Copyright © 2014. All rights reserved.
^ Back to Top