Histological and electron microscopic study of the

amounts of unhydrolysed DEHP DEHP is hydrolyzed in the gastrointestinal tract by a pancreatic lipase [4] DEHP is lipophilic and tends to accumulate in adipose tissue [5] The liver is one of the common sites of DEHP metabolism and utilization after oral exposure [3] Oral exposure of rats and mice to DEHP result in marked increase in

Request A Quotation!

Endocrine Studies

A study published in 2004 may help explain the different reactions from species to species In the study by Kessler et al 3 rats and marmosets were fed equivalent doses of DEHP and then tested for levels of MEHP which is a major metabolite of DEHP Blood levels of MEHP were as much as 7 5 times lower in the marmosets and the total

Request A Quotation!

Prenatal low

Publication date: 5 March 2020Source: Journal of Hazardous Materials Volume 385Author(s): Yun Fan Yufeng Qin Minjian Chen Xiuzhu Li Ruohan Wang Zhenyao Huang Qiaoqiao Xu Mingming Yu Yan Zhang Xiumei Han Guizhen Du Yankai Xia Xinru Wang Chuncheng LuAbstractDi-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitous environmental pollutant and is widely used in industrial plastics

Request A Quotation!

1 Introduction

Recently the activities of lipase UGT ADH and ALDH for DEHP metabolism in several organs were measured and compared among mice rats and marmosets [8] Marmosets were used as a reference to human Clear-cut species differences were seen in the activities of the four enzymes involved in the DEHP metabolism among mice rats and marmosets The most prominent difference was observed

Request A Quotation!

Phthalate Risks and Alternatives

In composting high concentrations of DEHP (60 mg/L or more) have been shown to decrease the rate of biodegradation of other phthalates from 48% to 6% due to partial metabolism and the production of 2-ethyl-hexanol which is toxic to the microorganism that degrades some phthalates

Request A Quotation!

Assessment of Possible Carcinogenic Risk to Humans

inferences consideration was given to such factors as genotoxicity metabolism and phar- macokinetics and physiological and biochemical effects of DEHP that might reveal its mechanism of action The relative merits of each of the various risk estimates are de- scribed based on current understanding of DEHP's mode of biological action

Request A Quotation!

Species differences in the metabolism of di(2

PD-11 Species differences in the metabolism of di(2-ethylhexyl)phthalate (DEHP) in several organs from mice rats and marmosets Yuki Ito1 Hiroshi Yokota2 Rui-Sheng Wang3 Osamu Yamanoshita1 Gaku Ichihara1 Hailan Wang1 Yoshimasa Kurata4 Tamie Nakajima1 1Department of Occupational and Environmental Health Nagoya University Graduate School of medicine Nagoya Japan 2Rakuno

Request A Quotation!

Diethylhexyladipat – Wikipedia

Gewinnung und Darstellung Industriell gewonnen wird DEHA durch Veresterung von Adipinsure mit 2-Ethylhexanol bei erhhten Temperaturen in Gegenwart von saueren Katalysatoren wie Schwefelsure oder p-Toluolsulfonsure Die Reinigung des Rohproduktes erfolgt durch die Abtrennung des Katalysators die Neutralisierung und das Abdampfen weiterer Verunreinigungen

Request A Quotation!

Di(2

DEHP has been shown to disrupt metabolic functions by regulating lipid biosynthesis in HepG2 cells (Zhang et al 2017) rats (Jia et al 2016b) mouse (Lv et al 2016) and in humans (Harley et al 2017) Our gene expression analysis in C elegans also revealed that both DEHP and DEP altered lipid metabolism To confirm that the gene

Request A Quotation!

Phthalate

Penetration andin vivo andin vitro metabolism studies using DEHP and chlorpyrifos (O O-diethyl0-(3 5 6-trichloro-2-pyridinyl) phosphorothioate) as model compounds indicated that DEHP when applied topically to house flies penetrated extremely slowly and was metabolized very slowly DEHP also was shown to exert an inhibitory effect on chlorpyrifos metabolismin vitro andin vivo Chlorpyrifos

Request A Quotation!

Effects Phthalate Esters on Lipid Metabolism in Various

Environmental HealthPerspectives Vol 45 pp 41-50 1982 Effects of Phthalate Esters on Lipid Metabolism in VariousTissues Cells and Organelles in Mammals by Frank P Bell* Theeffect ofphthalate ester plasticizers onavariety ofenzymesystemswasstudied in rats rabbitsandpigs Thefeedingofdi(2-ethylhexyl)phthalate(DEHP)toanimalsatlevelsfrom0 1% to1 0

Request A Quotation!

PPAR

However species differences were also seen in the lipase activity involved in the first step of the DEHP metabolism which should be considered in DEHP-induced carcinogenesis Taken together it is very difficult to extrapolate the results from rodents to humans in the case of DEHP carcinogenicity However PPAR-null mice or mice with human PPAR gene have been developed which may lend

Request A Quotation!

Liver Hypertrophy: A Review of

In practice drug- or chemical-induced hepatic hypertrophy tends to be a combination of all of these parameters in addition to others including profound changes in the intracellular enzymes involved not only in phase 1 and 2 drug metabolism (Crampton et al 1977b Lake Longland et al 1976 Maronpot et al 2010) but also in other more fundamental cell processes such as altered oxidative

Request A Quotation!

Effect of a hypolipidemic drug Di (2

Effect of a hypolipidemic drug Di (2-ethylhexyl) phthalate on mRNA-expression associated fatty acid and acetate metabolism in rat tissues Itsuki-Yoneda A Kimoto M Tsuji H Hiemori M Yamashita H Di (2-ehtylhexyl) phthalate (DEHP) is a peroxisome proliferator and a drug having a hypolipidemic effect

Request A Quotation!

Pediatric Exposure and Potential Toxicity of Phthalate

DEHP causes liver cancers 50 and DINP causes kidney and liver cancers in rodents 49 The mechanism of liver neoplasia caused by DEHP is believed to be attributable to peroxisome proliferation and a cascade of cellular events that do not occur in the human liver 51 but this theory remains to be confirmed 52 The mechanism of carcinogenesis of DINP in rodent liver is not fully understood but

Request A Quotation!

Distribution and elimination of di

The distribution and elimination of di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) after a single oral administration of DEHP (25 mmol/kg) were studied A gas-liquid Chromatographic method was used for the simultaneous determination of MEHP and DEHP The compounds were extracted with methylene chloride and the monoester was alkylated to the hexyl

Request A Quotation!

Prenatal low

Publication date: 5 March 2020Source: Journal of Hazardous Materials Volume 385Author(s): Yun Fan Yufeng Qin Minjian Chen Xiuzhu Li Ruohan Wang Zhenyao Huang Qiaoqiao Xu Mingming Yu Yan Zhang Xiumei Han Guizhen Du Yankai Xia Xinru Wang Chuncheng LuAbstractDi-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitous environmental pollutant and is widely used in industrial plastics

Request A Quotation!

RTECS:TI0350000

The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website

Request A Quotation!

Transcriptional deregulation of genetic biomarkers in

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental pollutant used worldwide as a plasticizer and solvent in many formulations Based on available toxicological data it has been classified as toxic for reproduction and as an endocrine disruptor Despite this ecotoxicological studies in aquatic wildlife organisms are still scarce

Request A Quotation!
Copyright © 2014. All rights reserved.
^ Back to Top